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In this podcast, Dr. Eleftherios Mylonakis, the Charles C.J. Carpenter Professor of Infectious Disease at The Warren Alpert Medical School, Brown University, discusses microbial pathogenesis, host responses, and more. Dr. Mylonakis is an infectious disease specialist who earned his medical degree from University of Athens. He has been practicing medicine for more than two decades.

Dr. Mylonakis discusses infectious diseases and the current research in drug discovery. He talks in detail about the important work being done in regard to resistant bacteria, specifically Methicillin-resistant Staphylococcus aureus (MRSA), which is a group of Gram-positive bacteria that are genetically distinct from other strains of Staphylococcus aureus. MRSA has been resistant to many antibiotics, which makes it a particularly difficult strain.

The Brown University doctor provides an overview of MRSA, discussing where it lives, and the pathways it takes to infiltrate body systems. Dr. Mylonakis states that human skin works as a successful barrier from the bacteria entering our bloodstream, for the most part, but as he says a cut on the skin or trauma from an accident, etc. can facilitate the bacteria’s infiltration into the bloodstream. Dr. Mylonakis explains how to identify virulence factors, and he provides useful and interesting information about the current research on the microbiome, talking in detail about how disruption can possibly lead to colonization. Continuing, the doctor talks about current diagnostics, and the extensive time doctors must sometimes wait for lab cultures before they can effectively understand what is going on. As many labs wait as long as up to 5 days before providing results, this can create problems with effectively treating toxicity and infection.

In this podcast:

  • What are virulence factors
  • Why are some strains of bacteria resistant to antibiotics
  • An overview of microbial pathogenesis
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